Long-term memory in Alzheimer's disease

Curr Opin Neurobiol. 1999 Apr;9(2):240-4. doi: 10.1016/s0959-4388(99)80034-8.


Recent findings have further characterized the neural and psychological bases of long-term memory failure in Alzheimer's disease. Convergent volumetric neuroimaging studies indicate that loss of episodic memory is specifically related to early-stage limbic-diencephalic pathology, and that non-mnemonic impairment is specifically related to later-stage temporal-neocortical pathology. Recent studies of Alzheimer's disease have also reported informative cognitive dissociations in semantic memory and implicit memory.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Aging / physiology
  • Alzheimer Disease / psychology*
  • Humans
  • Memory Disorders / physiopathology*
  • Semantics