Synaptic plasticity in cortical systems

Curr Opin Neurobiol. 1999 Apr;9(2):203-8. doi: 10.1016/s0959-4388(99)80028-2.


Recent studies indicate that synapse addition and/or loss is associated with different types of learning. Other factors influencing synaptogenesis and synapse loss include neurotrophins, hormones, and the induction of long-term potentiation. An emerging view of synaptic plasticity suggests that local neurotrophin action and synaptically associated protein synthesis may promote synaptic remodelling and changes in receptor expression or activation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cerebellum / physiology*
  • Cerebral Cortex / physiology*
  • Dendrites / metabolism
  • Hippocampus / physiology*
  • Long-Term Potentiation
  • Nerve Growth Factors / physiology
  • Nerve Tissue Proteins / biosynthesis
  • Neuronal Plasticity / physiology*


  • Nerve Growth Factors
  • Nerve Tissue Proteins