Gamma-tubulin complexes and their interaction with microtubule-organizing centers

Curr Opin Struct Biol. 1999 Apr;9(2):250-9. doi: 10.1016/S0959-440X(99)80035-9.

Abstract

Gamma-tubulin is as ubiquitous in eukaryotes as alpha- and beta-tubulin. Rather than forming part of the microtubule wall, however, gamma-tubulin is involved in microtubule nucleation. Although gamma-tubulin concentrates at microtubule-organizing centers, it also exists in a cytoplasmic complex whose size and complexity depends on the organism and cell type. In the past year, progress in understanding the functions of gamma-tubulin was made on two fronts: identifying the proteins that interact with gamma-tubulin and identifying the proteins that interact with the gamma-tubulin complex to tether it to the microtubule-organizing center.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Centrosome / chemistry*
  • Centrosome / metabolism*
  • Centrosome / ultrastructure
  • Cryoelectron Microscopy
  • Macromolecular Substances
  • Models, Molecular
  • Protein Conformation
  • Saccharomyces cerevisiae / metabolism
  • Tubulin / chemistry*
  • Tubulin / metabolism*
  • Tubulin / ultrastructure

Substances

  • Macromolecular Substances
  • Tubulin