Deciphering the timescales and mechanisms of protein folding using minimal off-lattice models

Curr Opin Struct Biol. 1999 Apr;9(2):197-207. doi: 10.1016/S0959-440X(99)80028-1.


Considerable insights into the mechanisms and timescales of protein folding have been obtained from detailed studies of minimal off-lattice models. These models are coarse-grained representations of polypeptide chains. Many novel predictions of the mechanisms and timescales of the folding of proteins have been made using simulations of off-lattice models. The concepts derived from these simulations have been used to analyze the recent experiments and simulations of proteins and peptides.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Kinetics
  • Models, Molecular*
  • Peptide Fragments / chemistry
  • Protein Folding*
  • Proteins / chemistry
  • RNA / chemistry
  • Temperature
  • Thermodynamics


  • Peptide Fragments
  • Proteins
  • RNA