The dynamics of HTLV-I and the CTL response

Immunol Today. 1999 May;20(5):220-7. doi: 10.1016/s0167-5699(99)01446-2.


Dominik Wodarz and colleagues describe a mathematical model for the in vivo dynamics of human T-cell leukaemia virus type 1 (HTLV-I) infection and the virus-specific cytotoxic T lymphocyte response. They show that a high rate of viral replication is consistent with the relative sequence invariance of HTLV-I and might be necessary to maintain a persistent infection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antiviral Agents / therapeutic use
  • HTLV-I Infections / drug therapy
  • HTLV-I Infections / immunology
  • HTLV-I Infections / virology
  • Human T-lymphotropic virus 1 / immunology*
  • Human T-lymphotropic virus 1 / physiology
  • Humans
  • Mathematics
  • Models, Biological
  • T-Lymphocytes, Cytotoxic / immunology*
  • Virus Replication


  • Antiviral Agents