Ligand-independent Activation of Steroid Receptors: New Roles for Old Players

Trends Endocrinol Metab. 1999 Mar;10(2):41-46. doi: 10.1016/s1043-2760(98)00121-0.


Steroid receptors are known as ligand-regulated transcription factors, but more and more evidence indicates that several steroid receptors can be activated in the absence of cognate hormone by agents that fall into three separate groups: peptide growth factors, the neurotransmitter dopamine and other agents that activate cAMP-dependent protein kinase A, and the cyclins A and D1.