The WD repeat: a common architecture for diverse functions

Trends Biochem Sci. 1999 May;24(5):181-5. doi: 10.1016/s0968-0004(99)01384-5.


Our knowledge of the large family of proteins that contain the WD repeat continues to accumulate. The WD-repeat proteins are found in all eukaryotes and are implicated in a wide variety of crucial functions. The solution of the three-dimensional structure of one WD-repeat protein and the assumption that the structure will be common to all members of this family has allowed subfamilies of WD-repeat proteins to be defined on the basis of probable surface similarity. Proteins that have very similar surfaces are likely to have common binding partners and similar functions.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Arabidopsis / chemistry
  • Caenorhabditis elegans / chemistry
  • Fungal Proteins / chemistry
  • GTP-Binding Proteins / chemistry
  • GTP-Binding Proteins / metabolism
  • Protein Conformation
  • Proteins / chemistry*
  • Proteins / metabolism*
  • Repetitive Sequences, Amino Acid*


  • Fungal Proteins
  • Proteins
  • GTP-Binding Proteins