Nedd4-like proteins: an emerging family of ubiquitin-protein ligases implicated in diverse cellular functions

Trends Cell Biol. 1999 May;9(5):166-9. doi: 10.1016/s0962-8924(99)01541-x.


The members of an emerging family of proteins similar to Nedd4 have a unique modular structure consisting of a Ca2+/lipid-binding domain, multiple protein-protein interaction modules and a ubiquitin-protein ligase domain. Although little is known about the physiological roles of these proteins, studies in both mammals and yeast are providing evidence that members of this family might be involved in diverse cellular functions, such as regulation of membrane channels and permeases, the cell cycle and transcription. This article attempts to bring together what is currently known about these evolutionarily conserved ubiquitin-protein ligases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcium-Binding Proteins / metabolism*
  • Endosomal Sorting Complexes Required for Transport
  • Eukaryotic Cells / chemistry
  • Eukaryotic Cells / enzymology*
  • Humans
  • Ligases / metabolism*
  • Nedd4 Ubiquitin Protein Ligases
  • Ubiquitin-Protein Ligases*
  • Ubiquitins / metabolism*


  • Calcium-Binding Proteins
  • Endosomal Sorting Complexes Required for Transport
  • Ubiquitins
  • Nedd4 Ubiquitin Protein Ligases
  • Nedd4 protein, human
  • Ubiquitin-Protein Ligases
  • Ligases