Histone deacetylases: transcriptional repression with SINers and NuRDs

Trends Cell Biol. 1999 May;9(5):193-8. doi: 10.1016/s0962-8924(99)01536-6.


The DNA in eukaryotic cells is packaged into chromatin, which functions as a boundary to the transcriptional activation process. The nucleosome is the basic repeating unit of chromatin. The purification and characterization of several chromatin-remodelling complexes and the demonstration that histone acetyltransferases and histone deacetylases are regulatory components of coactivator and corepressor complexes, respectively, demonstrates that the nucleosome is not simply a static architectural feature of chromatin but, rather, plays a dynamic and integral role in the regulation of gene expression. This review focuses primarily on histone deacetylases and deacetylase-containing complexes and their role in mediating transcriptional repression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Cell Nucleus / enzymology*
  • Chromatin / enzymology*
  • Histone Deacetylases / metabolism*
  • Repressor Proteins*
  • Saccharomyces cerevisiae Proteins*
  • Transcription Factors / metabolism*
  • Transcription, Genetic / physiology*


  • Chromatin
  • Repressor Proteins
  • SIN3 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Transcription Factors
  • Histone Deacetylases