[Clinical study on modified sijunzi decoction in treating intestinal metaplasia of gastric mucosa]

Zhongguo Zhong Xi Yi Jie He Za Zhi. 1997 Aug;17(8):462-4.
[Article in Chinese]


Objective: To investigate the effects of Modified Sijunzi decoction (MSJZD) in treating gastric pre-cancerous lesion.

Methods: Two hundreds and two patients with chronic gastritis and intestinal metaplasia (IM) of gastric mucosa diagnosed by gastroscopy and pathological examination of biopsy were divided into 2 groups, 117 cases of the treatment group were treated with MSJZD and 85 cases of the control group were treated with Weimeisu. For both groups, re-examination was taken after a 3-month treatment.

Results: The cure rate and total effective rate of IM in the treatment group were 55.6% and 87.2% respectively, while in the control group were 11.8% and 55.3% respectively (P < 0.01).

Conclusions: The intestinal metaplasia process of gastric mucosa is reversible and MSJZD has good effect on it. This study provided a new way of pre-cancerous lesion treatment and gastric cancer prevention.

Publication types

  • Clinical Trial
  • English Abstract
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Chronic Disease
  • Drugs, Chinese Herbal / therapeutic use*
  • Female
  • Gastric Mucosa / pathology*
  • Gastritis / drug therapy*
  • Humans
  • Male
  • Metaplasia / drug therapy
  • Middle Aged


  • Drugs, Chinese Herbal