Objective: To confirm the renal protective action of Astragalus Angelica mixture (AAM).
Methods: Effect of AAM was observed in puromycin amino-nucleoside induced nephrotic syndrome model of rat, and pravachol, an effective lipid lowering medicine, was used as positive control.
Results: AAM could not only reduce the serum levels of total cholesterol and triglyceride as pravachol did, but also could lower levels of low density lipoprotein and apolipoprotein B100 (P < 0.05). Light microscopic and immuno-histochemical examination revealed that in the same time of lowering serum lipids, this mixture could also cause reduction of glomerular sclerosing index (P < 0.01) and less accumulation of extracellular matrix (P < 0.01).
Conclusions: AAM has the effects of regulating lipid metabolism, attenuating renal damage and maintaining renal function in rats with nephrotic syndrome.