Best clinical practice: guidelines for managing major depression in primary medical care

J Clin Psychiatry. 1999:60 Suppl 7:19-26; discussion 27-8.


Practice guidelines such as those of the United States Public Health Service Agency for Health Care Policy and Research have been instrumental in addressing the significant problem of how best to manage major depression in primary medical care settings. Since this set of guidelines was published in 1993, new findings from randomized clinical trials and extensive clinical experience permit us to reevaluate trends in treatment of major depression in primary medical care. This review suggests guidelines for achieving best clinical practice given current knowledge.

Publication types

  • Review

MeSH terms

  • Antidepressive Agents / therapeutic use*
  • Antidepressive Agents, Tricyclic / therapeutic use
  • Cognitive Behavioral Therapy / standards
  • Combined Modality Therapy
  • Depressive Disorder / drug therapy
  • Depressive Disorder / psychology
  • Depressive Disorder / therapy*
  • Drug Administration Schedule
  • Health Care Costs
  • Humans
  • Practice Guidelines as Topic / standards*
  • Primary Health Care / standards*
  • Psychotherapy* / standards
  • Quality of Health Care
  • Randomized Controlled Trials as Topic
  • Selective Serotonin Reuptake Inhibitors / therapeutic use
  • Treatment Outcome
  • United States
  • United States Agency for Healthcare Research and Quality


  • Antidepressive Agents
  • Antidepressive Agents, Tricyclic
  • Serotonin Uptake Inhibitors