Sterol Regulatory Element-Binding Proteins: Activators of Cholesterol and Fatty Acid Biosynthesis

Curr Opin Lipidol. 1999 Apr;10(2):143-50. doi: 10.1097/00041433-199904000-00008.

Abstract

A family of transcription factors designated sterol regulatory element-binding proteins (SREBPs) mediates the previously described end-product feedback regulation of cholesterol biosynthesis. In addition, SREBPs are emerging as important regulators of fatty acid synthesis. The current review focuses on the in-vivo regulation of SREBPs in liver and the coordinate regulation of SREBP-activated target genes.

Publication types

  • Review

MeSH terms

  • Animals
  • CCAAT-Enhancer-Binding Proteins*
  • Cholesterol / biosynthesis*
  • DNA-Binding Proteins / metabolism*
  • DNA-Binding Proteins / physiology*
  • Fatty Acids / biosynthesis*
  • Gene Expression Regulation*
  • Liver / anatomy & histology
  • Liver / pathology
  • Mice
  • Mice, Transgenic
  • Models, Biological
  • Nuclear Proteins / metabolism*
  • Nuclear Proteins / physiology*
  • Sterol Regulatory Element Binding Protein 1
  • Transcription Factors*

Substances

  • CCAAT-Enhancer-Binding Proteins
  • DNA-Binding Proteins
  • Fatty Acids
  • Nuclear Proteins
  • Srebf1 protein, mouse
  • Sterol Regulatory Element Binding Protein 1
  • Transcription Factors
  • Cholesterol