[Recurrent osteitis and Coxiella burnetii: the relation to chronic recurrent multifocal osteomyelitis]

Arch Pediatr. 1998 Mar;5(3):291-4. doi: 10.1016/s0929-693x(97)89372-4.
[Article in French]


Chronic recurrent multifocal osteomyelitis (CRMO) is a disorder of suspected--but unproved-infectious etiology.

Observation: A girl presented with a typical CRMO involving successively the left fibula, radius, humerus and the right carpus. A Coxiella burnetii infection was indicated during the first attack. Two recurrences occurred in spite of suitable antibiotic treatment and with negative infectious investigation. Two months after stopping antibiotic treatment, a new recurrence associated with antibodies increase and positive bone culture occurred.

Conclusion: Coxiella burnetii can initiate a CRMO. The mechanism involved is probably a delayed hypersensitivity. CRMO would therefore be the first type of reactive osteitis.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Carpal Bones / microbiology
  • Child, Preschool
  • Chronic Disease
  • Coxiella burnetii / classification
  • Female
  • Fibula / microbiology
  • Humans
  • Humerus / microbiology
  • Osteitis / microbiology*
  • Osteomyelitis / microbiology*
  • Q Fever*
  • Radius / microbiology
  • Recurrence


  • Anti-Bacterial Agents