Podophyllotoxin in serum: absorption subsequent to three-day repeated applications of a 0.5% ethanolic preparation on condylomata acuminata

Sex Transm Dis. Jan-Mar 1982;9(1):26-33.

Abstract

High-performance liquid chromatography was used for quantitative determination of podophyllotoxin in serum subsequent to repeated applications of a 0.5% ethanolic preparation on condylomata acuminata. The drug was not detectable in the serum of ten men treated with < or = 50 microliters. In serum of seven patients receiving 100-1,500 microliters on extraordinarily large en-plaque lesions, peak levels of 1-17 ng/ml were measured within 1-2 hr. The drug did not accumulate in serum. Dispersion of 100 microliters gave rise to peak levels of < or = 5.0 ng/ml and to subsequent levels of < or = 3.0 ng/ml for 4 hr. Larger doses gave rise to traceable amounts in serum for < or = 12 hr. Investigations with 52 patients indicated that volumes of > 100 microliters are rarely required for topical treatment of condylomata. It is concluded that application of volumes of < or = 250 microliters twice daily for three days would satisfy the most stringent safety precautions and avoid any danger of systemic toxicity. Potential hazards associated with use of the nonstandardized 20% podophyllin preparations are emphasized.

MeSH terms

  • Absorption
  • Administration, Cutaneous
  • Adolescent
  • Adult
  • Aged
  • Chromatography, High Pressure Liquid
  • Condylomata Acuminata / drug therapy*
  • Drug Administration Schedule
  • Female
  • Humans
  • Keratolytic Agents / administration & dosage*
  • Keratolytic Agents / blood*
  • Keratolytic Agents / pharmacokinetics
  • Male
  • Middle Aged
  • Podophyllotoxin / administration & dosage*
  • Podophyllotoxin / blood*
  • Podophyllotoxin / pharmacokinetics
  • Treatment Outcome

Substances

  • Keratolytic Agents
  • Podophyllotoxin