The cause of the fall in serum folate in normal pregnancy

Br J Obstet Gynaecol. 1976 Feb;83(2):132-6. doi: 10.1111/j.1471-0528.1976.tb00794.x.


Study of a complete antenatal population, a group of normal primigravid singleton pregnancies, and a group of normal twin pregnancies, suggests that the fall in the serum folate concentration which occurs in normal pregnancy is due principally to plasma volume expansion and should therefore be regarded as physiological.

MeSH terms

  • Adult
  • Female
  • Folic Acid / blood*
  • Folic Acid Deficiency / epidemiology
  • Humans
  • Parity
  • Plasma Volume
  • Postpartum Period
  • Pregnancy Trimester, Third
  • Pregnancy*
  • Pregnancy, Multiple*
  • Smoking
  • Social Class
  • Twins


  • Folic Acid