New synthetic heparin mimetics able to inhibit thrombin and factor Xa

Bioorg Med Chem Lett. 1999 Apr 19;9(8):1155-60. doi: 10.1016/s0960-894x(99)00155-9.

Abstract

Synthetic pentadeca-, heptadeca- and nonadecasaccharides, comprising an antithrombin III (AT III) binding pentasaccharide prolonged at the non-reducing end by a thrombin binding domain have been obtained. The pentadecasaccharide is the shortest oligosaccharide able to catalyse thrombin inhibition by AT III. The nonadecasaccharide is a more potent thrombin inhibitor than standard heparin.

MeSH terms

  • Carbohydrate Sequence
  • Factor Xa Inhibitors*
  • Heparin / analogs & derivatives*
  • Heparin / chemical synthesis*
  • Heparin / pharmacokinetics*
  • Models, Chemical
  • Molecular Sequence Data
  • Thrombin / antagonists & inhibitors*

Substances

  • Factor Xa Inhibitors
  • Heparin
  • Thrombin