Structure-based design of diaminopyranosides as a novel inhibitor core unit of HIV proteases

Bioorg Med Chem Lett. 1999 Apr 19;9(8):1179-84. doi: 10.1016/s0960-894x(99)00154-7.


Novel HIV PR inhibitors, which contain a diaminopyranoside moiety as an inhibitor core unit, were designed based on the 3D structures of complexes of HIV-1 PR with transition-state mimics. These compounds were examined for their ability to inhibit the hydrolytic activity of a recombinant HIV-1 PR.

MeSH terms

  • Amino Acids, Diamino / chemical synthesis*
  • Amino Acids, Diamino / chemistry*
  • Amino Acids, Diamino / pharmacokinetics*
  • Drug Design*
  • HIV Protease Inhibitors / chemical synthesis*
  • HIV Protease Inhibitors / chemistry*
  • HIV Protease Inhibitors / pharmacokinetics*
  • Models, Chemical


  • Amino Acids, Diamino
  • HIV Protease Inhibitors