Altitude-related pulmonary disorders

Crit Care Clin. 1999 Apr;15(2):265-80, viii. doi: 10.1016/s0749-0704(05)70054-3.


The major physiologic stress encountered at high altitude is caused by the occurrence of hypobaric hypoxia. In this article, acute and chronic pulmonocardiac adaptation to altitude is reviewed, including possible genetic differences among highlanders from the Himalayan versus the Andean Mountains. The origin, symptoms, and treatment of acute mountain sickness and high altitude pulmonary edema are outlined. In addition, the prediction and prevention of pulmonary complications that may be encountered or exacerbated during commercial airflight are noticed.

Publication types

  • Review

MeSH terms

  • Altitude Sickness / physiopathology
  • Altitude*
  • Animals
  • Humans
  • Lung Diseases / etiology*
  • Lung Diseases / physiopathology
  • Lung Diseases / therapy
  • Pulmonary Edema / etiology
  • Pulmonary Edema / physiopathology
  • Respiration
  • Sleep Wake Disorders / etiology