Phylogenetic analysis of primate MIC (PERB11) sequences suggests that the representation of the gene family differs in different primates: comparison of MIC (PERB11) and C4

Eur J Immunogenet. Apr-Jun 1999;26(2-3):233-8. doi: 10.1046/j.1365-2370.1999.00154.x.


Duplication of segments within the MHC has led to numerous multicopy families such as class I, class II, C4 and MIC (PERB11). Different copy numbers between haplotypes and species may be explained by the extent of duplication and subsequent deletion. There are at least five copies of MIC (PERB11) in humans, but MICA (PERB11.1) appears to have been deleted from the chimpanzee. By comparing the sequences of primates (chimpanzee, gorilla, gibbon, orang-utan, pygmy chimpanzee, Patas monkey, Aethiops and baboon) we conclude that the gorilla has a copy of PERB11.1, whereas the baboon and Patas possess MICD (PERB11.4) and/or MICE (PERB11.5) rather than MICA (PERB11.1). These findings indicate that the primate MHC is more plastic than has been appreciated.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Complement C4 / genetics*
  • Genes, MHC Class I / genetics*
  • Histocompatibility Antigens Class I / classification
  • Histocompatibility Antigens Class I / genetics*
  • Humans
  • Mice
  • Molecular Sequence Data
  • Phylogeny*
  • Polymorphism, Genetic
  • Primates / genetics*
  • Proteins / genetics*
  • RNA, Long Noncoding
  • RNA, Untranslated
  • Sequence Alignment


  • Complement C4
  • HCG9 non-protein coding RNA, human
  • Histocompatibility Antigens Class I
  • MHC class I-related chain A
  • Proteins
  • RNA, Long Noncoding
  • RNA, Untranslated