A new genetic distance with application to constrained variation at microsatellite loci

Mol Biol Evol. 1999 Apr;16(4):467-71. doi: 10.1093/oxfordjournals.molbev.a026128.

Abstract

Genetic variation at microsatellite loci is supposed to be constrained within some range in allele size. In this case, the average-square distance (delta mu)2 between two diverged populations moves asymptotically around and underestimates the time since the populations had split. A distance based on the between-locus correlation in the mean repeat scores, DR, is introduced. Numerical simulations show that DR is a linear function of time if the constraints are approximated by a linear centripetal force, which might be due to mutation bias toward a definite range or be caused both by directional mutation bias toward larger allele size and by selection against the greater number of repeats.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles
  • Evolution, Molecular
  • Genetic Variation*
  • Microsatellite Repeats*
  • Models, Genetic
  • Mutation
  • Phylogeny*
  • Repetitive Sequences, Nucleic Acid