TALL-1 is a novel member of the TNF family that is down-regulated by mitogens

J Leukoc Biol. 1999 May;65(5):680-3.


Members of the tumor necrosis factor (TNF) family play important roles in modulation of immune responses. We describe the identification and cloning of a novel TNF family member that has been designated as TALL-1. TALL-1 is a 285-amino acid type II transmembrane protein. Its carboxy terminus shares approximately 35% sequence identity with the recently identified APRIL and approximately 20-25% with TNF, FasL, TRAIL, and lymphotoxin-alpha, suggesting that TALL-1 and APRIL belong to a subfamily of the TNF family of ligands. Northern blot analysis suggests that TALL-1 is expressed abundantly in peripheral blood leukocytes and weakly in spleen but is barely detectable in all other tissues examined. Reverse transcriptase-polymerase chain reaction analysis indicates that TALL-1 is specifically expressed in monocytes and macrophages but is undetectable in T and B lymphocytes. Furthermore, TALL-1 expression is dramatically down-regulated by phorbol myristate acetate/ionomycin.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • B-Cell Activating Factor
  • Cloning, Molecular
  • Down-Regulation / drug effects
  • Down-Regulation / immunology*
  • Humans
  • Ligands
  • Membrane Proteins / biosynthesis*
  • Membrane Proteins / chemistry
  • Membrane Proteins / genetics
  • Mitogens / pharmacology*
  • Molecular Sequence Data
  • Rabbits
  • Sequence Homology, Amino Acid
  • Tumor Necrosis Factor Ligand Superfamily Member 13
  • Tumor Necrosis Factor-alpha / biosynthesis*
  • Tumor Necrosis Factor-alpha / chemistry
  • Tumor Necrosis Factor-alpha / genetics


  • B-Cell Activating Factor
  • Ligands
  • Membrane Proteins
  • Mitogens
  • TNFSF13 protein, human
  • TNFSF13B protein, human
  • Tumor Necrosis Factor Ligand Superfamily Member 13
  • Tumor Necrosis Factor-alpha

Associated data

  • GENBANK/AF136293
  • GENBANK/AF136294