Representations of hindlimb digits in rat dorsal root ganglia

J Comp Neurol. 1999 May 24;408(1):137-45. doi: 10.1002/(sici)1096-9861(19990524)408:1<137::aid-cne10>3.0.co;2-3.

Abstract

The distribution in dorsal root ganglia of neurones that innervate the distal tips of the hindlimb digits in the rat were mapped after subcutaneous injections of the fluorescent tracers Fast Blue, Diamidino Yellow, and Fluoro-Gold into different digits. Three-dimensional reconstruction was used to describe the intraganglionic distribution of neurones labelled from different digits. Labelled neurones were found mainly in the L3-L5 ganglia. The distribution in ganglia and the number of neurones labelled from each digit varied considerably between cases, but mean numbers of labelled neurones were similar for the different digits. Neurones in L3 tended to innervate medial digits and neurones in L5 tended to innervate lateral digits, but most neurones from any digit were found in L4. Although overlap was considerable, the three-dimensional reconstruction showed tendencies of neurones to be distributed in restricted territories within the dorsal root ganglia. This was especially clear in ganglion L5, where digit IV was found to be represented more rostrally than digit V. The results indicate that primary afferent neurones that innervate the hindlimb digits are represented by a crude rostrocaudal somatotopic organisation both among and within lumbar dorsal root ganglia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Afferent Pathways / anatomy & histology
  • Animals
  • Female
  • Ganglia, Spinal / anatomy & histology*
  • Hindlimb / anatomy & histology*
  • Hindlimb / innervation
  • Nerve Regeneration
  • Rats
  • Rats, Sprague-Dawley