Abstract
We describe 2 cases of polyarthralgia-arthritis syndrome induced by rifabutin, an effective treatment for infections of Mycobacterium avium intracellulare complex. This syndrome has been reported with doses higher than 1 g per day when rifabutin is given in monotherapy. But our cases were treated with low doses, 300-450 mg per day, in combination with clarithromycin. The plasma concentration of rifabutin has been shown to be increased by clarithromycin, suggesting that co-prescription of clarithromycin could lead to development of rifabutin induced polyarthralgia-arthritis syndrome.
MeSH terms
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Anti-Bacterial Agents / therapeutic use
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Antibiotics, Antitubercular / administration & dosage
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Antibiotics, Antitubercular / adverse effects*
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Antibiotics, Antitubercular / therapeutic use
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Arthralgia / chemically induced*
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Arthritis / chemically induced*
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Clarithromycin / therapeutic use
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Drug Interactions
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Drug Therapy, Combination
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Female
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Humans
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Male
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Middle Aged
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Mycobacterium avium-intracellulare Infection / drug therapy
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Rifabutin / administration & dosage
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Rifabutin / adverse effects*
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Rifabutin / therapeutic use
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Syndrome
Substances
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Anti-Bacterial Agents
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Antibiotics, Antitubercular
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Rifabutin
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Clarithromycin