Comparison of albumin versus bicarbonate treatment for neonatal metabolic acidosis

Eur J Pediatr. 1999 May;158(5):414-5. doi: 10.1007/s004310051104.


In this study the effectiveness of 4.5% human albumin was compared with 4.2% sodium bicarbonate for neonatal metabolic acidosis, using a randomised controlled trial. The change in median pH following bicarbonate was more than twice that in the albumin group. This was statistically significant.

Conclusion: In normotensive infants, use of bicarbonate to correct metabolic acidosis may be more effective than use of albumin.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Acidosis / metabolism
  • Acidosis / therapy*
  • Humans
  • Hydrogen-Ion Concentration
  • Infant, Newborn
  • Serum Albumin / therapeutic use*
  • Sodium Bicarbonate / therapeutic use*


  • Serum Albumin
  • Sodium Bicarbonate