Phosphoinositide kinases and the synthesis of polyphosphoinositides in higher plant cells

Int Rev Cytol. 1999;189:95-130. doi: 10.1016/s0074-7696(08)61386-8.

Abstract

Phosphoinositides are a family of inositol-containing phospholipids which are present in all eukaryotic cells. Although in most cells these lipids, with the exception of phosphatidylinositol, constitute only a very minor proportion of total cellular lipids, they have received immense attention by researchers in the past 15-20 years. This is due to the discovery that these lipids, rather than just having structural functions, play key roles in a wide range of important cellular processes. Much less is known about the plant phosphoinositides than about their mammalian counterparts. However, it has been established that a functional phosphoinositide system exists in plant cells and it is becoming increasingly clear that inositol-containing lipids are likely to play many important roles throughout the life of a plant. It is not our intention to give an exhaustive overview of all aspects of the field, but rather we focus on the phosphoinositide kinases responsible for the synthesis of all phosphorylated forms of phosphatidylinositol. Also, we mention some of the aspects of current phosphoinositide research which, in our opinion, are most likely to provide a suitable starting point for further research into the role of phosphoinositides in plants.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Eukaryotic Cells / metabolism
  • Humans
  • Phosphatidylinositol 3-Kinases / metabolism
  • Phosphatidylinositol Phosphates / biosynthesis*
  • Phosphatidylinositols / metabolism*
  • Phosphotransferases / metabolism*
  • Plant Cells
  • Plants / metabolism*

Substances

  • Phosphatidylinositol Phosphates
  • Phosphatidylinositols
  • Phosphotransferases
  • Phosphatidylinositol 3-Kinases