Eye development: Notch lends a handedness

Curr Biol. 1999 May 20;9(10):R356-60. doi: 10.1016/s0960-9822(99)80226-7.

Abstract

The arrangement of photoreceptors in the ommatidia of the Drosophila compound eye is polarized, having a handedness or chirality. Notch signalling helps determine this handedness, first by establishing a signalling center at the eye equator, and second by mediating a choice between two photoreceptor fates

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Drosophila / embryology*
  • Drosophila / genetics
  • Drosophila Proteins
  • Eye / embryology*
  • Eye / growth & development
  • Membrane Proteins / metabolism*
  • Mutation
  • Photoreceptor Cells, Invertebrate / metabolism
  • Receptors, Notch
  • Signal Transduction

Substances

  • Drosophila Proteins
  • Membrane Proteins
  • N protein, Drosophila
  • Receptors, Notch