Fire-diffuse-fire model of dynamics of intracellular calcium waves

Proc Natl Acad Sci U S A. 1999 May 25;96(11):6060-3. doi: 10.1073/pnas.96.11.6060.


When Ca2+ is released from internal stores in living cells, the resulting wave of increased concentration can travel without deformation (continuous propagation) or with burst-like behavior (saltatory propagation). We analyze the "fire-diffuse-fire" model in order to illuminate the differences between these two modes of propagation. We show that the Ca2+ release wave in immature Xenopus oocytes and cardiac myocytes is saltatory, whereas the fertilization wave in the mature oocyte is continuous.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Female
  • Fertilization
  • Intracellular Fluid / metabolism
  • Kinetics
  • Models, Biological*
  • Myocardium / metabolism*
  • Oocytes / physiology*
  • Xenopus


  • Calcium