Glucotoxicity: potential mechanisms

Clin Geriatr Med. 1999 May;15(2):255.


Plasma concentration of glucose is found within a relatively narrow range of values for most animal species, yet it has little correlation with maximum lifespan; however, hyperglycemia in most animals is associated with premature death. This article presents evidence for hyperglycemia-induced tissue toxicity and discusses potential mechanisms of glucotoxicity and implications for the aging organism.

Publication types

  • Review

MeSH terms

  • Age Factors
  • Aged
  • Animals
  • Diabetes Complications*
  • Female
  • Glucose / adverse effects
  • Glucose / metabolism*
  • Humans
  • Hyperglycemia / etiology*
  • Hyperglycemia / physiopathology
  • Male
  • Oxidative Stress
  • Risk Assessment


  • Glucose