Biological factors which may influence an older child's or adolescent's responses to toxic chemicals

Abstract

Currently, there is considerable interest in scientific and regulatory issues relating to protection of children's health. Attention to date has largely been focused on establishing the efficacy and safety of drugs in children and on assessing potential risks of pesticides and similar agents to infants and young children. Older children and adolescents, however, have received little attention as special subgroups at risk from exposure to toxic and carcinogenic chemicals. Adolescence is the second most rapid period of growth and development, after infancy. Several organ systems experience substantial structural and functional changes during puberty. Attention is focused in this review on the more important organ systems that are undergoing maturation and therefore may be the most likely to exhibit aberrant responses to toxicants. Attention is also paid to age-related changes in processes which govern the disposition and metabolism of chemicals in the body.