Leukemia Inhibitory Factor, Interleukin 6, and Other Cytokines Using the GP130 Transducing Receptor: Roles in Inflammation and Injury

Stem Cells. 1999;17(3):127-37. doi: 10.1002/stem.170127.


Inflammation refers to a complex set of mechanisms by which tissues respond to injury and infection. Among the many soluble mediators associated with this process, cytokines are known to be crucial in regulating a variety of cellular and molecular events. Leukemia inhibitory factor (LIF), interleukin 6 (IL-6), IL-11, and possibly other members of this cytokine family are key mediators in various inflammatory processes such as the acute-phase reaction, tissue damage, and infection. These cytokines can act in both pro-inflammatory and anti-inflammatory ways, depending on a number of variables. We emphasize here recent work utilizing knockout mice, which has highlighted the roles of LIF and IL-6, particularly in interactions between the immune and nervous systems.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antigens, CD / physiology*
  • Cytokine Receptor gp130
  • Growth Inhibitors / physiology*
  • Humans
  • Inflammation / metabolism*
  • Interleukin-11 / physiology
  • Interleukin-6 / physiology*
  • Leukemia Inhibitory Factor
  • Lymphokines / physiology*
  • Membrane Glycoproteins / physiology*
  • Mice
  • Mice, Knockout
  • Wounds and Injuries / metabolism*


  • Antigens, CD
  • Growth Inhibitors
  • IL6ST protein, human
  • Il6st protein, mouse
  • Interleukin-11
  • Interleukin-6
  • LIF protein, human
  • Leukemia Inhibitory Factor
  • Lif protein, mouse
  • Lymphokines
  • Membrane Glycoproteins
  • Cytokine Receptor gp130