Antibodies to cardiolipin and beta2-glycoprotein-1 in HTLV-1-associated myelopathy/tropical spastic paraparesis

Lupus. 1999;8(3):210-4. doi: 10.1191/096120399678847731.


Anticardiolipin and anti-beta2GP1 antibodies were measured in 50 patients with HTLV-1-associated Myelopathy-Tropical Spastic Paraparesis (HAM-TSP) and the results were compared with those obtained for 34 HTLV-1-positive and 35 HTLV-1-negative controls, as well as 128 SLE patients. aCL but not anti-beta2GP1 was associated with HTLV-I infection. aCL was more prevalent than anti-beta2GP1 (32% vs. 8%) and was not associated with anti-beta2GP1 in HAM-TSP. IgA was the dominant isotype of aCL and anti-beta2GP1. The data suggest that tin HAM-TSP, IgA aCL are frequent and are associated with HTLV-1 infection.

MeSH terms

  • Antibodies, Anticardiolipin / blood*
  • Antibodies, Antiphospholipid / blood*
  • Case-Control Studies
  • Glycoproteins / immunology*
  • HTLV-I Infections / immunology
  • Humans
  • Immunoglobulin A / blood
  • Immunoglobulin Isotypes / blood
  • Lupus Erythematosus, Systemic / immunology
  • Paraparesis, Tropical Spastic / immunology*
  • beta 2-Glycoprotein I


  • Antibodies, Anticardiolipin
  • Antibodies, Antiphospholipid
  • Glycoproteins
  • Immunoglobulin A
  • Immunoglobulin Isotypes
  • beta 2-Glycoprotein I