Herpesvirus saimiri as a model for gammaherpesvirus oncogenesis

Semin Cancer Biol. 1999 Jun;9(3):231-9. doi: 10.1006/scbi.1998.0115.


Herpesvirus saimiri (HVS) causes T-lymphoproliferative dis-$borders in several New World and Old World primate species and in certain rabbits.In vitro infection leads to permanent growth of primary T cells of primate and human origins. The transformation-relevant proteins of HVS interact with cellular proto-oncoproteins which results in cell growth transformation. In addition, virus-encoded cellular homologues may contribute to transformation or persistence of HVS by altering cellular signal transduction and deregulating cell growth control. Because of the presence of a permissive cell culture system and in vitro Land in vivo transformation assays, HVS provides a unique opportunity to investigate the mechanisms of cancer induction by oncogenic herpesviruses.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Transformation, Neoplastic
  • Disease Models, Animal
  • Herpesvirus 2, Saimiriine / genetics*
  • Humans
  • Lymphocyte Activation
  • Neoplasms / etiology*
  • Oncogenes
  • Phosphoproteins / physiology
  • Primates
  • Rabbits
  • Viral Proteins / physiology


  • Phosphoproteins
  • Viral Proteins
  • tyrosine kinase interacting protein, Saimiriine herpesvirus 2