Identifying inner retinal contributions to the human multifocal ERG

Vision Res. 1999 Jun;39(13):2285-91. doi: 10.1016/s0042-6989(98)00296-x.


Contributions to the multifocal electroretinogram (ERG) from the inner retina (i.e. ganglion and amacrine cells) were identified by recording from monkeys before and after intravitreal injections of n-methyl DL aspartate (NMDLA) and/or tetrodotoxin (TTX). Components similar in waveform to those removed by the drugs were identified in the human multifocal ERG if the stimulus contrast was set at 50% rather than the typically employed 100% contrast. These components were found to be missing or diminished in the records from some patients with glaucoma and diabetes, diseases which affect the inner retina.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Animals
  • Diabetic Retinopathy / physiopathology
  • Electroretinography / drug effects*
  • Glaucoma, Open-Angle / physiopathology
  • Humans
  • Macaca mulatta
  • Middle Aged
  • N-Methylaspartate / pharmacology
  • Pattern Recognition, Visual / physiology
  • Retina / physiology*
  • Retina / physiopathology
  • Retinal Ganglion Cells / physiology
  • Tetrodotoxin / pharmacology


  • Tetrodotoxin
  • N-Methylaspartate