New MRI findings in Creutzfeldt-Jakob disease: high signal in the globus pallidus on T1-weighted images

Neuroradiology. 1999 Apr;41(4):265-8. doi: 10.1007/s002340050744.


We report a 49-year-old woman with Creutzfeldt-Jakob disease (CJD). In addition to typical high-signal lesions on proton-density and T2-weighted images there was high signal in the globus pallidus bilaterally on T1-weighted images. The latter feature has not been described previously and probably due to deposition of prion protein, as found at autopsy.

Publication types

  • Case Reports

MeSH terms

  • Caudate Nucleus / pathology
  • Contrast Media
  • Creutzfeldt-Jakob Syndrome / diagnosis
  • Creutzfeldt-Jakob Syndrome / pathology*
  • Fatal Outcome
  • Female
  • Gadolinium DTPA
  • Globus Pallidus / pathology*
  • Gyrus Cinguli / pathology
  • Humans
  • Image Processing, Computer-Assisted / methods
  • Immunohistochemistry
  • Magnetic Resonance Imaging / methods*
  • Middle Aged
  • Prions / analysis
  • Putamen / pathology


  • Contrast Media
  • Prions
  • Gadolinium DTPA