A new antibiotic nortriterpene quinone methide from Maytenus catingarum

J Nat Prod. 1999 May;62(5):750-1. doi: 10.1021/np980359p.

Abstract

15alpha-Hydroxy-21-keto-pristimerine (1), a new nortriterpene quinone methide was isolated from the root bark of Maytenus catingarum along with other well-known related compounds, including pristimerine (2), tingenone, and 20alpha-hydroxy-tingenone. The structure of 1 was determined by means of 1H and 13C NMR spectroscopy, including homonuclear and heteronuclear correlations. Compound 1 showed antibiotic activity against Gram-positive bacteria.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Candida albicans / drug effects
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Norsteroids / isolation & purification
  • Norsteroids / pharmacology
  • Plant Roots / chemistry
  • Rosales / chemistry*
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet

Substances

  • 15-hydroxy-21-ketopristimerine
  • Anti-Bacterial Agents
  • Norsteroids