Solitary fibrous tumor of the oral cavity: an uncommon location for a ubiquitous neoplasm

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999 May;87(5):589-93. doi: 10.1016/s1079-2104(99)70139-3.


Solitary fibrous tumor is an uncommon soft tissue tumor initially reported in the pleura but recently described in other sites of the body. To date, only 5 examples of oral solitary fibrous tumor have been reported. Here, we describe 2 additional cases of this tumor in the oral cavity. The tumors were composed of small to medium-sized spindle cells with bland cytologic features; these cells were haphazardly arranged in highly cellular sheets or ill-formed fascicles as well as in hypocellular areas with hyalinized blood vessels. Both tumors contained blood vessels with a hemangiopericytomalike appearance and expressed vimentin, CD34, and CD99. One case was also strongly positive for bcl-2. The diagnosis of solitary fibrous tumor may be difficult inasmuch as it shares a number of histologic features with other soft tissue tumors. Awareness of its occurrence in the oral cavity is important so that confusion with other spindle cell neoplasms can be avoided.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Diagnosis, Differential
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Male
  • Mouth Neoplasms / chemistry
  • Mouth Neoplasms / pathology*
  • Neoplasm Proteins / analysis
  • Neoplasms, Fibrous Tissue / chemistry
  • Neoplasms, Fibrous Tissue / pathology*
  • Soft Tissue Neoplasms / chemistry
  • Soft Tissue Neoplasms / pathology*
  • Vimentin / analysis


  • Neoplasm Proteins
  • Vimentin