Studies on the anti-inflammatory and analgesic activity of Cedrus deodara (Roxb.) Loud. wood oil

J Ethnopharmacol. 1999 Apr;65(1):21-7. doi: 10.1016/s0378-8741(98)00150-0.

Abstract

The volatile oil extracted by steam distillation of the wood of Cedrus deodara was examined for its oral anti-inflammatory and analgesic activity at the doses of 50 and 100 mg/kg body weight. It produced significant inhibition of carrageenan-induced rat paw edema and of both exudative-proliferative and chronic phases of inflammation in adjuvant arthritic rats at doses of 50 and 100 mg/kg body weight. The oil at both tested doses was found to possess analgesic activity against acetic acid-induced writhing and hot plate reaction in mice.

MeSH terms

  • Acetic Acid / adverse effects
  • Analgesics / therapeutic use*
  • Animals
  • Anti-Inflammatory Agents / therapeutic use*
  • Arthritis, Experimental / drug therapy*
  • Carrageenan / adverse effects
  • Edema / drug therapy*
  • Inflammation / chemically induced
  • Mice
  • Oils / therapeutic use
  • Pain Measurement / methods
  • Plant Extracts / therapeutic use*
  • Rats

Substances

  • Analgesics
  • Anti-Inflammatory Agents
  • Oils
  • Plant Extracts
  • Carrageenan
  • Acetic Acid