Validity of height velocity as a diagnostic criterion for idiopathic growth hormone deficiency and Turner syndrome

Horm Res. 1999;51(2):68-73. doi: 10.1159/000023317.


A deflecting growth curve over several years is sometimes the only indication for the possible presence of a growth disorder. In this study we looked at the potential diagnostic role of long-term downward deflection of the growth curve. It reports on the diagnostic validity of height velocity over 1, 2 or 3 years for isolated idiopathic growth hormone deficiency and for Turner syndrome in prepubertal children with a height that is still above -2.5 standard deviation scores (SDS). 1-year height velocity was found to have no diagnostic value because of an almost complete overlap of height velocity distributions with normal prepubertal children. However, height velocity over 3 years was found to have an acceptable validity in children 5-12 years old. In this age range a change in height SDS of -0.75 can be used as a valid criterion for further examination of karyotype and GH secretion capacity even if there are no other clear signs of a particular growth disorder.

Publication types

  • Clinical Trial

MeSH terms

  • Body Height / physiology*
  • Child
  • Child, Preschool
  • Female
  • Human Growth Hormone / deficiency*
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Netherlands
  • Predictive Value of Tests
  • Reproducibility of Results
  • Turner Syndrome / diagnosis*
  • Turner Syndrome / physiopathology


  • Human Growth Hormone