Effect of Choto-san, a kampo medicine, on impairment of passive avoidance performance in mice

Phytother Res. 1999 May;13(3):233-5. doi: 10.1002/(SICI)1099-1573(199905)13:3<233::AID-PTR416>3.0.CO;2-R.


In mice with procephalic ischaemia loading, disrupted passive avoidance retention performance was dose-dependently improved by Choto-san, but this effect was antagonized by NAN-190, a serotonin1A receptor antagonist. In mice with decreased intracerebral serotonin concentration, Choto-san prevented disturbance in acquiring a passive avoidance response after scopolamine administration, but did not influence the decreased serotonin concentration. These results suggested that Choto-san showed the anti-amnestic effect based on the stimulation of serotonin1A receptors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Avoidance Learning / drug effects*
  • Cerebral Cortex / drug effects
  • Cerebral Cortex / metabolism
  • Drugs, Chinese Herbal / pharmacology*
  • Male
  • Mice
  • Mice, Inbred ICR
  • Piperazines / pharmacology
  • Serotonin / metabolism
  • Serotonin Antagonists / pharmacology


  • Drugs, Chinese Herbal
  • Piperazines
  • Serotonin Antagonists
  • choto-san
  • 1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine
  • Serotonin