Regulation of leukocyte trafficking by lipoxins

Clin Chem Lab Med. 1999 Mar;37(3):293-7. doi: 10.1515/CCLM.1999.051.


Lipoxins are lipoxygenase interaction products formed by transcellular metabolism during host defence and inflammation. In model systems, lipoxins modulate polymorphonuclear leukocytes (PMN) chemotaxis, adhesion molecule expression, inhibit PMN-endothelial cell adhesion, and attenuate cytokine release from epithelial cells. These observations raise the possibility that lipoxins are 'stop signals' for PMN-mediated tissue injury and promote the resolution of acute inflammation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Arachidonic Acids / biosynthesis
  • Arachidonic Acids / physiology*
  • Cell Adhesion / physiology
  • Chemotaxis, Leukocyte / physiology*
  • Endothelium, Vascular / cytology
  • Humans
  • Neutrophils / cytology*


  • Arachidonic Acids