Regulation and characterization of the Na+/H+ exchanger

Biochem Cell Biol. 1998;76(5):735-41. doi: 10.1139/bcb-76-5-735.


The Na+/H+ exchanger is a ubiquitous protein present in all mammalian cell types that functions to remove one intracellular H+ for one extracellular Na+. Several isoforms of the protein exist, which are referred to as NHE1 to NHE6 (for Na+/H+ exchanger one through six). The NHE1 protein was the first isoform cloned and studied in a variety of systems. This review summarizes recent papers on this protein, particularly those that have examined regulation of the protein and its expression and activity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cytoplasm / metabolism
  • Gene Expression Regulation
  • Humans
  • Hydrogen-Ion Concentration
  • Models, Biological
  • Rabbits
  • Rats
  • Saccharomyces cerevisiae / metabolism
  • Sodium-Hydrogen Exchangers / chemistry*
  • Sodium-Hydrogen Exchangers / physiology*


  • Sodium-Hydrogen Exchangers