Severe respiratory syncytial virus disease in Alaska native children. RSV Alaska Study Group

J Infect Dis. 1999 Jul;180(1):41-9. doi: 10.1086/314841.


Hospitalization rates for respiratory syncytial virus (RSV) infection range from 1 to 20/1000 infants. To determine the rate and severity of RSV infections requiring hospitalization for infants in the Yukon-Kuskokwim (YK) Delta of Alaska, a 3-year prospective surveillance study was conducted. The annual rate of RSV hospitalization for YK Delta infants <1 year of age was 53-249/1000. RSV infection was the most frequent cause of infant hospitalization. RSV disease severity did not differ among non-high-risk infants in the YK Delta and at Johns Hopkins Hospital (JHH). On average, 1/125 infants born in the YK Delta required mechanical ventilation for RSV infection. During the peak season, approximately $1034/child <3 years of age was spent on RSV hospitalization in the YK Delta. In YK Delta infants </=6 months old, RSV microneutralizing antibody titers <1200 were associated with severe disease (odds ratio=6.2, P=.03). In the YK Delta and at JHH, newborns may be at greater risk for severe RSV illness than previously thought.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Alaska / epidemiology
  • Antibodies, Viral / blood
  • Baltimore / epidemiology
  • Child, Preschool
  • Fetal Blood / immunology
  • Hospitalization
  • Hospitals, Community
  • Humans
  • Incidence
  • Indians, North American
  • Infant
  • Infant, Newborn
  • Inuits
  • Population Surveillance
  • Prospective Studies
  • Respiratory Syncytial Virus Infections / economics
  • Respiratory Syncytial Virus Infections / epidemiology*
  • Respiratory Syncytial Viruses / classification
  • Risk Factors
  • Seasons
  • Severity of Illness Index


  • Antibodies, Viral