Serum G-CSF levels are not increased in patients with antibody-induced neutropenia unless they are suffering from infectious diseases

Br J Haematol. 1999 Jun;105(3):616-7. doi: 10.1046/j.1365-2141.1999.01390.x.


By the use of a G-CSF-specific ELISA we determined the serum granulocyte-colony stimulating factor (G-CSF) levels in 63 patients with antibody-induced neutropenia including neonatal immune neutropenia, autoimmune neutropenia, and drug-induced immune neutropenia. In the sera of 20 patients, elevated G-CSF levels of 60-1006 pg/ml (normal <39 pg/ml) were observed. These patients suffered from infectious diseases at the time of blood collection. G-CSF levels normalized after successful antibiotic treatment, indicating that increased G-CSF production in patients with immune neutropenia may be primarily the result of infection and not of neutropenia.

MeSH terms

  • Adult
  • Autoantibodies / immunology
  • Autoimmune Diseases / blood*
  • Autoimmune Diseases / etiology
  • Autoimmune Diseases / immunology
  • Enzyme-Linked Immunosorbent Assay
  • Granulocyte Colony-Stimulating Factor / blood*
  • Humans
  • Infant
  • Infant, Newborn
  • Infections / blood*
  • Isoantibodies / immunology
  • Neutropenia / blood*
  • Neutropenia / chemically induced
  • Neutropenia / immunology


  • Autoantibodies
  • Isoantibodies
  • Granulocyte Colony-Stimulating Factor