Brain abscess caused by Cladosporium trichoides (Bantianum): a case with paranasal sinus involvement

South Med J. 1976 Nov;69(11):1519-21. doi: 10.1097/00007611-197611000-00038.


Dematiacious fungi (ie, fungi with dark hyphae) are a rare and usually fatal cause of central nervous system infection. Cladosporium trichoides has been implicated most frequently. Documentation of extra-CNS involvement has been rare. Our patient had a brain abscess and paranasal sinus infection due to C trichoides. The organism was sensitive to less than or equal 2mug/ml of flucytosine. Although our patient did not receive flucytosine, it is possible that this drug, because of its excellent penetration into the cerebrospinal fluid, may be a useful therapeutic agent in cerebral cladosporiosis.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Brain Abscess / drug therapy
  • Brain Abscess / etiology*
  • Cladosporium*
  • Flucytosine / therapeutic use
  • Humans
  • Male
  • Middle Aged
  • Mitosporic Fungi*
  • Mycoses* / drug therapy
  • Sinusitis / drug therapy


  • Flucytosine