Restricted expression of the receptor serine/threonine kinase BMPR-IB in zebrafish

Mech Dev. 1999 Apr;82(1-2):219-22. doi: 10.1016/s0925-4773(99)00023-4.


Bone morphogenetic proteins (BMPs) comprise a rapidly expanding subclass of the transforming growth factor-beta superfamily. They are known to regulate a diverse range of developmental phenomena including cell differentiation, morphogenesis and apoptosis. In this study, we have isolated a zebrafish homolog of BMP type IB receptor (BMPR-IB) and examined the localization of the transcripts during embryogenesis. Whole-mount in situ hybridization analysis revealed that unlike other type I and type II receptors that mediate BMP signal, it is expressed in developing somite and in mid-hind brain region in a restricted manner.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Bone Morphogenetic Protein Receptors, Type I
  • Cloning, Molecular
  • Gene Expression Regulation, Developmental
  • Gene Expression Regulation, Enzymologic
  • Humans
  • In Situ Hybridization
  • Mesencephalon / embryology
  • Mesencephalon / enzymology
  • Molecular Sequence Data
  • Phylogeny
  • Protein-Serine-Threonine Kinases / genetics*
  • Receptors, Growth Factor / genetics*
  • Somites / enzymology
  • Zebrafish / embryology*
  • Zebrafish / genetics*


  • Receptors, Growth Factor
  • Protein-Serine-Threonine Kinases
  • BMPR1B protein, human
  • Bone Morphogenetic Protein Receptors, Type I