All aboard the cyclin train: subcellular trafficking of cyclins and their CDK partners

Trends Cell Biol. 1999 Jun;9(6):207-10. doi: 10.1016/s0962-8924(99)01577-9.


Progression through the cell cycle is governed by the periodic activation and inactivation of cyclin-dependent kinase complexes (CDK-cyclins). Although the enzymatic activity of these complexes is regulated tightly, it has recently been demonstrated that an additional facet of cell-cycle control involves the modulation of CDK-cyclin subcellular localization. Recent discoveries include the identification of nuclear transport factors responsible for ferrying some of the CDK-cyclins in and out of the nucleus, the demonstration that phosphorylation can regulate these transport processes and the establishment of potential links between cell-cycle checkpoints and the control of CDK-cyclin subcellular localization.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Nucleus / metabolism
  • Cyclin-Dependent Kinases / metabolism*
  • Cyclins / metabolism*
  • Cytoplasm / metabolism
  • G1 Phase / physiology
  • G2 Phase / physiology
  • Humans
  • Mitosis / physiology
  • S Phase / physiology


  • Cyclins
  • Cyclin-Dependent Kinases