AKAPs: from structure to function

Trends Cell Biol. 1999 Jun;9(6):216-21. doi: 10.1016/s0962-8924(99)01558-5.


Compartmentalization of signalling molecules through association with anchoring proteins ensures specificity in signal transduction by placing enzymes close to their appropriate effectors and substrates. For example, 'A-kinase anchoring proteins' (AKAPs) bind to the regulatory subunit of cAMP-dependent protein kinase (PKA) to direct the kinase to discrete intracellular locations. Recently, functional studies aimed at disrupting AKAP-PKA complexes have demonstrated a role for anchored PKA in various cellular processes, including gene transcription, hormone-mediated insulin secretion and ion-channel modulation. By binding to additional signalling molecules, AKAPs might function to coordinate multiple components of signal-transduction pathways.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Carrier Proteins / metabolism*
  • Carrier Proteins / physiology*
  • Cell Compartmentation / physiology
  • Cyclic AMP / metabolism
  • Cyclic AMP-Dependent Protein Kinases / metabolism*
  • Membrane Proteins / metabolism*
  • Membrane Proteins / physiology*
  • Protein Binding / physiology
  • Signal Transduction / physiology


  • Carrier Proteins
  • Membrane Proteins
  • Cyclic AMP
  • Cyclic AMP-Dependent Protein Kinases