Pathoadaptive mutations: gene loss and variation in bacterial pathogens

Trends Microbiol. 1999 May;7(5):191-5. doi: 10.1016/s0966-842x(99)01493-6.


Pathogenicity-adaptive, or pathoadaptive, mutations represent a genetic mechanism for enhancing bacterial virulence without horizontal transfer of specific virulence factors. Pathoadaptive evolution can be important within single infections and for defining the population structure of a pathogenic species.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adaptation, Physiological
  • Bacterial Physiological Phenomena*
  • Evolution, Molecular
  • Genes, Bacterial*
  • Genetic Variation
  • Humans
  • Mutation*