Applications of mass spectrometry to signal transduction

Prog Biophys Mol Biol. 1999;71(3-4):501-23. doi: 10.1016/s0079-6107(98)00048-0.


Advances in mass spectrometry instrumentation, protocols for sample handling, and computational methods provide powerful new approaches to solving problems in analytical biochemistry. This review summarizes recent work illustrating ways in which mass spectrometry has been used to address questions relevant to signal transduction. Rather than encompass all of the instruments or methodologies that might be brought to bear on these problems, we present an overview of commonly used techniques, promising new methodologies, and some applications.

Publication types

  • Review

MeSH terms

  • Animals
  • Biochemistry / methods
  • Humans
  • Lipids / analysis
  • Lipids / physiology
  • Mass Spectrometry / instrumentation
  • Mass Spectrometry / methods*
  • Protein Conformation
  • Protein Folding
  • Protein Processing, Post-Translational
  • Proteins / chemistry*
  • Proteins / metabolism
  • Signal Transduction*


  • Lipids
  • Proteins